1. Most human chromosomes are metacentric or submetacentric, but a small number are acrocentric, with the centromere located very close to one end.(大部分人类染色体是中央着、次着中央,但少数是接近末端的端着中央)
2. Acrocentric chromosomes are known for their role in certain genetic disorders, such as Down syndrome.(在某些遗传疾病,例如唐氏综合症中,端着中央染色体扮演着重要角色)